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Arousal from sleep and sympathetic excitation during wakefulness

Under hypoxia, when the flux through the tricarboxylic acid (TCA) cycle is attenuated due to HIF-1mediated inhibition of pyruvate dehydrogenase (via PDK1), glutamine becomes increasingly important for anaplerosisthe replenishment of TCA cycle intermediates necessary for the synthesis of macromolecules (79, 90)